COVID-19

WHO Advice on Coronavirus disease (COVID-19) Pandemic

Public, country and technical advice: WHO COVID-19 Guidelines

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National clinical guidelines for COVID-19

The National COVID-19 Clinical Evidence Taskforce is supporting Australia’s healthcare professionals with continually updated, evidence-based clinical guidelines: https://covid19evidence.net.au/

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Surviving Sepsis Campaign Guidelines for COVID-19

Now available: Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill
Adults with Coronavirus Disease 2019 (COVID-19) see: SSC COVID-19 Guidelines and Resources

Background

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, Coronavirus Disease 2019 (COVID-19), affecting thousands of people around the world. Urgent guidance for clinicians caring for the sickest of these patients is needed.

Methods

We formed a panel of 36 experts from 12 countries. All panel members completed the World Health
Organization conflict of interest disclosure form. The panel proposed 53 questions that are relevant to the management of COVID-19 in the ICU. We searched the literature for direct and indirect evidence on the management of COVID-19 in critically ill patients in the ICU. We identified relevant and recent systematic reviews on most questions relating to supportive care. We assessed the certainty in the evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach, then generated recommendations based on the balance between benefit and harm, resource and cost implications, equity, and feasibility. Recommendations were either strong or weak, or in the form of best practice recommendations.

Results

The Surviving Sepsis Campaign COVID-19 panel issued 54 statements, of which 4 are best practice
statements, 9 are strong recommendations, and 35 are weak recommendations. No recommendation was provided for 6 questions. The topics were: 1) infection control, 2) laboratory diagnosis and specimens, 3) hemodynamic support, 4) ventilatory support, and 5) COVID-19 therapy.

Conclusion

The Surviving Sepsis Campaign COVID-19 panel issued several recommendations to help support healthcare workers caring for critically ill ICU patients with COVID-19. When available, we will provide new evidence in further releases of these guidelines.